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Al space. Indeed, HMGB1 levels are increased in the serum and synovial fluid of patients with rheumatoid arthritis (RA).92,93 The use of recombinant HMGB1 demonstrated that extracellular HMGB1 promotes the macrophageand neutrophil-dependent development of arthritis.93,94 HMGB1 is actively secreted by synovial macrophages and fibroblasts in collagen-induced arthritis and hypoxic conditions.95 In t
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Al space. Indeed, HMGB1 levels are increased in the serum and synovial fluid of patients with rheumatoid arthritis (RA).92,93 The use of recombinant HMGB1 demonstrated that extracellular HMGB1 promotes the macrophageand neutrophil-dependent development of arthritis.93,94 HMGB1 is actively secreted by synovial macrophages and fibroblasts in collagen-induced arthritis and hypoxic conditions.95 In t
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