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And disrupting microtubule architecture [5]. Protein kinase C (PKC) is a serine/threonine protein kinase family; PKC family members are classified into three major groups based on their activation pathways [6]: classical PKC isotypes (, I, II and ) are activated by diacylglycerol (DAG) and calcium, novel PKC isotypes (, , and ) are activated by DAG, and atypical PKC isotypes ( and /) are not reg
70 chaperone system consists of Hsp70, Hsp40, and a nucleotide exchange factor (Hsp70 has an ATPase activity). Although the ATP-bound form of Hsp70 has a low affinity for substrates due to its high substrate exchange rate, the ADP-bound form has a higher affinity for substrates with a low substrate exchange rate. Hsp40 acts as a co-chaperone and activates the Hsp70 ATPase, although it also acts a
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